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    2022-11-30 06:19:25÷˹ҽѧ
    ʾȻȺʸߴ1015֪ȻĸֲȾɫ塢ӹ쳣ڷ쳣صȣȻDZڻԲٴнϴȻIJ޷

    ȻȺʸߴ10-15%֪ȻĸֲȾɫ塢ӹ쳣ڷ쳣صȣȻDZڻԲٴнϴȻIJ޷͡


    ӹĤϸ(ESC) ĤϸDSCķֻ̳ΪĤDecidualizationһ̵쳣ȱŮԲСȻﲢ֢ءӹĤĤΪȻһҪԭ򡣹ӹĤĤ̻ϸڵĶϸĽ󡢸طֲ

    оĤеĹؼ¼ػƶڽʾDZڵưеͿµƲԾҪֵڣѧҽԺŶӡͬôѧһӤԺƼŶӺ͸ѧŴ̹صʵԽԪŶӺɵо˴л;ϸֻĤеĵػƼȻеҪãṩµֶο

    2022-11-30Science Advances־ԡFructose-16-bisphosphate prevents pregnancy loss by inducing decidual COX-2+ macrophage differentiationΪⷢ˸оɹоʾ˴лʧĤϸֻ쳣Ȼ»ƣ״α16ڷȻеļֵ

    оռߵӹĤϸ(ESCs)ȺĤϸDSCsȶԭESCsDSCsдлѧ˺ܶǴл;IJ﷢仯16-ǣfructose-16-bisphosphate FBPĤϸߣͼ1A֤ʵ鷢FBPߵ֯кߣѪͬҲӣͼ1BǽͽƼ2-deoxy-d-glucose2-DGСʣ2-DGСвFBPʣ˵FBPdzɹĹؼӣͼ1Cùɹ-16-˫ø1µ6-Ǽø1ϵ鵼

    оռESCsFBPESCsϸ˿оƬʵ飬ɸѡؼϸӡFBPESCsIL-27ͼ1DEIL-27raIL-27Ψһ壬о߷IL-27raȱʧĴСӣͼ1FGЩ˵ĤϸFBPͨϸIL-27ĺIL-27źͨ·ٽĤȷɹ

    FBPεIL-27ڵأо֤FBPͨٽIL-27ת¼c-FOSERK1/2ữʵãͼ2A֮оͨ20K൰оƬFBPERK/c-FOS/IL-27źͨ·Ļơ-6-ᣨG6PоƬ69FBPԽϵףͼ2B69װFOSIL-27MAPK1ףγɽܵĵ׻磬PKM2ǺFOSMAPKĵĵףͼ2CоƬ˵PKM2FBPERK/c-FOS/IL-27źŵĹؼףFBPͨPKM2/ERK/c-FOSͨ·IL-27ڣFBPֱͨӽЩ׷õġоƬɸѡFBPԽϵΪоӻƵ춨˻

    ͼ2о߿չ˸ĻоFBP-IL-27źſӾϸCOX-2ĸ߱ٽCOX-2+M2ϸͼ3AӶӹĤĤϸϮĸ̥ܡתCOX-2+ϸԤIL-27壨Il27raȱʧС̥ʧϸעIL-27raȱʧСʣCOX-2ȱʧľϸɥʧЧͼ3B˵FBP/IL-27źͨCOX-2+ϸķֻáڸУFBP/IL-27COX-2+ϸ٣ͼ3CFBPСģͣʣͼ3D˵FBPΪµĴҩ

    ʵϣ16-ǣFDPǽͽ;һҪлмΪһٴϣFDPΪǴлøĻԺͻָϸлķˮƽҩݿˡļļֱѪܼΣ˽θӪƷȼƺ͸ơҲڸ߼Ѫ֢µļˡԳ˺ۺļӪѭΪƣнϺЧһΪԤﶪʧDZƲṩ˿ѧݣѻùҷרȨרţCN108387722B

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    Zhou WJ Yang HL Mei J et al.Fructose-16-bisphosphate prevents pregnancy loss by inducing decidual COX-2 + macrophage differentiation. [J]. Sci Adv. 2022;8(8)eabj2488.

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